Improvement of quality of life through glycemic control by liraglutide, a GLP-1 analog, in insulin-naive patients with type 2 diabetes mellitus: the PAGE1 study
نویسندگان
چکیده
BACKGROUND In addition to achieving good glycemic control, diabetes care management aims to improve the quality of life (QOL) in patients. Treatment-associated difficulties and side effects frequently cause deterioration in QOL. Liraglutide, a GLP-1 receptor agonist, is a novel injection drug that promotes insulin secretion. It is a user-friendly, once-daily injection with fewer hypoglycemic events. In this study, we aimed to examine the effect of liraglutide therapy on QOL in patients. METHODS In total, 304 insulin- and liraglutide-naïve patients with type 2 diabetes were enrolled in this observational study; they received liraglutide therapy for 12 weeks. The main outcome measure was change in QOL from baseline, which was assessed using diabetes therapy-related QOL (DTR-QOL). RESULTS At week 12, liraglutide significantly decreased HbA1c levels (8.7 ± 1.5 vs. 7.5 ± 1.3, p < 0.001) and BMI (27.9 ± 5.3 vs. 27.3 ± 5.2, p < 0.001). According to the QOL scores, although the treatment modality had changed from non-injection to injection therapy, liraglutide improved patient satisfaction with treatment. Significant correlations were found between change in HbA1c level and satisfaction with treatment, as well as between change in body weight and burden on social and daily activities, anxiety and dissatisfaction with treatment, and hypoglycemia. CONCLUSIONS Liraglutide significantly improved glycemic control and reduced the body weight without deteriorating QOL in obese patients with type 2 diabetes. Trial registration UMIN-CTR: UMIN000007159.
منابع مشابه
Liraglutide, a long-acting human GLP-1 Analog, given as Monotherapy Significantly Improves Glycemic Control and Lowers Body Weight without Risk of Hypoglycemia in Patients with Type 2 Diabetes Mellitus Running title: Effect of liraglutide on glycemic control and weight
متن کامل
Liraglutide, a glucagon-like peptide-1 (GLP-1) agonist, has been shown to improve glycemic control in individuals with type 2 diabetes mellitus (T2DM) who fail to achieve blood glucose targets (A1c<7.0%) on metformin and sulfonylureas alone
Liraglutide, a glucagon-like peptide-1 (GLP-1) agonist, has been shown to improve glycemic control in individuals with type 2 diabetes mellitus (T2DM) who fail to achieve blood glucose targets (A1c<7.0%) on metformin and sulfonylureas alone 1. The concurrent use of liraglutide with insulin, however, has not been extensively reported2,3,4. In this year-long observational study we assess the effi...
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Type 2 diabetes mellitus (T2DM) is a progressive disease associated with significant morbidity and mortality. There is good evidence that intensive glycemic control reduces the development and progression of complications in patients with diabetes. In order to achieve glycemic targets, patients often require a combination of oral therapy and/or insulin in addition to lifestyle modification. Unf...
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INTRODUCTION Glucagon-like peptide-1 (GLP-1) receptor agonists are used successfully in the treatment of patients with type 2 diabetes as they are associated with low hypoglycemia rates, weight loss and improved glycemic control. This study compared, in the Spanish setting, the cost-effectiveness of liraglutide 1.8 mg versus lixisenatide 20 μg, both GLP-1 receptor agonists, for patients with ty...
متن کاملLiraglutide therapy beyond glycemic control: an observational study in Indian patients with type 2 diabetes in real world setting
BACKGROUND Liraglutide is an analog of human glucagon-like peptide-1 (GLP-1) and acts as a GLP-1 receptor agonist. Liraglutide is presently used in the treatment of selected patients with type 2 diabetes mellitus (T2DM). OBJECTIVE To assess efficacy and safety of liraglutide in, overweight and obese Indian patients with T2DM. METHODS A single center, prospective, open-labeled, single-arm, o...
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عنوان ژورنال:
دوره 9 شماره
صفحات -
تاریخ انتشار 2017